SP-0439 Extreme hypofractionation in the treatment of localized prostate cancer

Moderate hypofractionation for prostate cancer

At the end of the last century, Brenner and Hall [1] argued that the fractionation sensitivity of prostate cancer was different from most tumors and normal tissues, with the opportunity to increase the therapeutic ratio by treating this cancer with hypofractionation (fewer, larger daily fractions). Nearly two decades later, the use of moderate hypofractionation for prostate cancer has become an...

Hypofractionation: what does it mean for prostate cancer treatment?

PURPOSE Using current radiobiologic models and biologic parameters, we performed an exploratory study of the clinical consequences of hypofractionation in prostate cancer radiotherapy. METHODS AND MATERIALS Four hypofractionated treatment regimens were compared with standard fractionation of 2 Gy x 39 for prostate carcinoma using a representative set of anatomical structures. The linear-quadr...

Hypofractionation trials and radiobiology of prostate cancer

SBRT and extreme hypofractionation: A new era in prostate cancer treatments?

AIM Radiation therapy (RT) is a standard therapeutic option for prostate cancer (PC). In the last decades, several innovative technology applications have been introduced. 3-Dimensional conformal RT, volumetric/rotational intensity modulated RT associated or not with image-guided RT, are becoming largely diffused in the treatment of PC. BACKGROUND Considering that PC could have a low α/β rati...

Optimal Treatment Strategy in Localized Prostate Cancer

detail_view&confID=40&abstractID=34492; cited May 8, 2008] 25. Hodgson D, Urbach D, Przybysz R, Gong Y, Sullivan T, Rabeneck L. Cancer surgery. Chapter 2. In: Tu JV, Pinfold SP, McColgan P, Laupacis A, eds. Access to Health Services in Ontario. Toronto: Institute for Clinical Evaluative Sciences; April 2005: 10. [Available online at: www.ices.on.ca/WebBuild/ site/ices-internet-upload/file_colle...